Predictive value of plasma D-Dimer and fibrinogen degradation products on prognosis of acute coronary syndrome

Objective: To investigate the clinical value of combined detection of plasma D-Dimer and fibrinogen degradation products (FDP) on predicting the prognosis of patients with acute coronary syndrome (ACS). Methods: 126 patients confirmed of ACS at our hospital were selected in this study, and divided into two groups-observation group (68 cases, with MACE) and control group (58 cases, without MACE), according to the occurrence of major adverse cardiovascular events (MACE). The levels of D-Dimer, FDP, PT, INR and PLT were detected and compared between the two groups. The patients were followed-up for 1 year, and the occurrence of MACE in two groups was recorded. Logistic regression analysis was used to analyze the risk factors for the occurrence of MACE in ACS patients. ROC curve was used to evaluate the best cutoff points of D-Dimer and FDP to predict MACE in ACS patients. Results: The plasma levels of D-Dimer and FDP in observation group were obviously higher than those in control group (t=3.175, 3.629, P < 0.05), however, the differences in the indices of PLT, PT and INR were not statistically significant between two groups (P > 0.05). The plasma levels of D-Dimer and FDP were confirmed to be the risk factors for the occurrence of MACE by multivariate logistic regression analysis. The area under ROC curve for D-Dimer and FDP alone in predicting MACE for ACE patients was 0.796 and 0.682 respectively (P=0.014, 0.028). But, with the cut-off point of 0.64 mg/L for D-Dimer and 2.26 μg/L for FDP, the AUC of combined prediction of D-Dimer and FDP was 0.857, and the sensitivity, specificity and accuracy for the prediction were 46.6%, 78.3% and 56.8%, respectively. Conclusion: The combined detection of plasma D-Dimer and FDP has good predictive value for the occurrence of MACE in patients with ACS.